What’s Oleoylethanolamide (OEA)?

Oleoylethanolamide (OEA) is a naturally occurring lipid molecule that regulates appetite, fat metabolism, and energy balance. With the CAS number 111-58-0, OEA is also referred to as N-Oleoylethanolamide. This white to off-white powder has the molecular formula C20H39NO2 and a molecular weight of 325.53 g/mol. It is soluble in ethanol and other organic solvents but insoluble in water. Key benefits of OEA supplements include promoting weight management by reducing hunger and supporting healthy lipid metabolism, making it popular in dietary supplements aimed at weight control and metabolic health.

Oleoylethanolamide consists of three words: oleoyl ethanol amide (so you can pronounce and memorize it more easily). However, Oleoylethanolamide is still too long for users to learn, and experts use OEA to refer to it. (The first letter of the three words)

Oleoylethanolamide is a natural metabolite of oleic acid made in the small intestine within the human body. It is naturally occurring, and experts call it “endogenous.”

Structures of OEA

OEA binds with high affinity to the peroxisome-proliferator-activated receptor-a (PPAR-a), a nuclear receptor regulating several aspects of lipid metabolism.

Natural sources of oleoylethanolamide

The OEA ingredient is a natural metabolite of oleic acid. Therefore, foods containing oleic acid are a direct source of OEA.

Oleic acid is the primary fat in vegetable oils such as olive, canola, and sunflower. It can also be found in nut oils, meat, poultry, and cheese.

Dietary sources rich in oleic acid include:

· Canola Oil

· Olive Oil

· Avocado Oil

· Almond Oil

· Avocados

· High Oleic Safflower Oil

Some facts about Oleic Acid:

· One of the most common fats in human breast milk

· Makes up 25% of fat in cow’s milk

· Monounsaturated

· Omega-9 fatty acid

· Chemical formula is C18H34O2(CAS 112-80-1)

· Hangs out with triglycerides

· It is used in high-priced cosmetics as a very effective moisturizer

· Found in milk fat, cheese, olive oil, grapeseed oil, nuts, avocados, eggs and meat

· It may be responsible for most of the health benefits of olive oil.

The manufacturing process of Oleoylethanolamide

The flow chart of Oleoylethanolamide is below:

The Oleoylethanolamide (OEA) powder manufacturing process involves synthesis, purification, and filtration to ensure high purity. The compound is then re-dissolved in ethanol, followed by hydrogenation and crystallization for stability and quality. After final filtration and rigorous testing, the purified OEA powder is packaged for distribution,

If you have questions regarding the technical process, please feel free to contact us.

Benefits of OEA Supplements

Oleoylethanolamide (OEA) is a naturally occurring lipid with numerous health benefits. It is widely studied for its roles in appetite regulation, weight management, cardiovascular health, and neuroprotection. Known for signaling satiety, OEA helps control hunger, support weight loss efforts, and enhance fat metabolism. Additionally, it may positively impact cardiovascular health by promoting balanced lipid levels, and its neuroprotective properties contribute to brain health and mood regulation, making it a valuable addition to dietary supplements.

· Appetite suppression: Helps manage hunger by signaling fullness, aiding in weight control.

· Weight management: Supports fat metabolism, assisting in healthy weight loss.

· Cardiovascular health: Promotes balanced cholesterol levels for heart health.

· Neuroprotection: Potentially protects brain cells, contributing to long-term brain health.

· Mood regulation: May positively influence mood by affecting brain function.

Oleoylethanolamide (OEA) is not an FDA-approved drug or dietary supplement in the U.S. and is not intended to diagnose, treat, prevent, or cure any disease. Consult a healthcare professional before use.

Please email us if you want to buy oleoylethanolamide OEA for sale or know OEA pricing and technical documents such as the certificate of analysis and MSDS.