THYMOQUINONE CAS 490-91-5 Anthraquinones Plant extract Nigella sativa Antioxidant Anti-cancer Phytochemical

Description:

Thymoquinone (TQ) is a chief bioactive constituent of black seed oil (Nigella sativa). TQ holds promising pharmacological properties against several diseases. It exhibits outstanding antioxidant, anti-inflammatory, anticancer, and other important biological activities. TQ effectively transforms cancer progression signaling pathways. It not only improves anticancer activity of chemotherapeutic drugs but also attenuates their side effects. 

Chemical Formula:

Definition:

Thymoquinone is a member of the class of 1,4-benzoquinones that is 1,4-bezoquinone in which the hydrogens at positions 2 and 5 are replaced by methyl and isopropyl groups, respectively. It is a natural compound isolated from Nigella sativa which has demonstrated promising chemotherapeutic activity. It has a role as an anti-inflammatory agent, an antioxidant, an adjuvant, an antineoplastic agent, a cardioprotective agent, an antidepressant and a plant metabolite.

Anti-cancer Research

The black cumin (Nigella sativa) that has a long history of medicinal use contains aphytochemical called thymoquinone (2-methyl-5-isopropyl-1,4-benzoquinone)(Padhye et al. 2008; Khan et al. 2011). In the regions of Southeastern Asia, Africa,Arab and the Mediterranean, the black cumin seeds have a notable history in traditionalmedicine practices. In ancient Egypt, Greece and Turkey, black cumin seedswere often used to treat many diseases and ailments (Padhye et al. 2008; Salih et al.2009; Khan et al. 2011; Ahmad et al. 2013). The Nigella sativa plant seeds and oilare used for medicinal purposes, and they are known for their hepatoprotective,renal-protective, antimicrobial, antidiabetic, anticancer, antihypertensive, analgesic,anti-inflammatory, immunomodulatory, spasmolytic, gastro-protective, bronchodilativeand antioxidant activities (Salih et al. 2009; Khan et al. 2011; Ahmad et al.2013). Recently, Barkat et al. (2017) reported that administration of thymoquinoneto  acts on cell cycle and inhibits progression from G1 to S phase bytargeting the cell cycle-related proteins such as cyclin D1, cyclin E and p27. It alsoexhibits histone deacetylase (HDAC) inhibitory effects, targets p21 and Maspin andinduces pro-apoptotic gene, Bax, and downregulates anti-apoptotic gene Bcl-2(Barkat et al. 2017).

Package:25kg fiber drum